It's Scientific Fraud

Animal-based research is as reliable as flipping a coin. This is due to the vast number of differences between species including genetic, physiological, metabolic and psychological differences. 

Vivisection isn’t just barbaric because of the high level of suffering and pain that it inflicts on animals but also because it acts under the false guise of being for the greater good of human health.

Animal-based researchers want us to believe that animal experimentation has to happen if we want to save the lives of humans; this is a dangerous misconception that is wasting lives, resources and time.

In reality animal-based research is as reliable as flipping a coin. This is due to the vast number of differences between species including genetic, physiological, metabolic and psychological differences.

We believe that animal-based research is not instrumental to the future of human health as the risk it poses to both animals and humans outweighs the benefits.

 

Sometimes drugs react the same in humans as they do in animals. Sometimes they act differently and other times species ‘A’ will react one way, species ‘B’ will react another and species ‘C’ (humans) will react in an entirely different way.

The best example to highlight the different ways that species can react is with penicillin. Rabbits, guinea pigs, rats and mice all react differently to penicillin.

Penicillin is:

- Metabolised too quickly in rabbits

- Fatal for guinea pigs

- Teratogenic in rats (causes limb malformations in offspring)

- Effective in mice

The use of penicillin in humans was held back years because of the response shown in the rabbit experiments. This is just one of the many examples where the results from animal based research have harmed humans. In this case by prolonging the development of useful drugs/medicines for humans.

 

In summary, sometimes animals react the same as humans (like the mice did in the penicillin example). These are the “success stories” that animal-based researchers will cling to. They don’t, however, talk about the many treatments and cures we miss out on because of the misleading results shown by animal experiments. They also don’t talk about the times where drugs that work in animals have gone on to hurt or be fatal to humans.  

 

The most famous example is the Thalidomide Disaster. In the 1950s thalidomide was prescribed to pregnant mothers to alleviate morning sickness (after it had been tested on animals). The animal tests showed no adverse side effects. This unfortunately wasn’t the case for humans as it caused over 10,000 birth defects where babies were born with malformed limbs that were either not developed properly or were presented as stumps. Read more here

Other Dangerous drugs

With 9/10 experimental drugs failing in humans that have worked in animals, it is no surprise that there are many examples where humans have had unexpected responses to drugs due to misleading animal experiments.  

Here is a list of cases where animal experiments have failed to predict the human response (This is not a complete list, it is just a few of the many examples):

 

Drug

Purpose

Result

Amrinone

To treat heart failure

Caused thrombocytopenia - a lack of blood cells needed for clotting in 20% of patients taking the drug on a long term basis.

Ariprazole

An antipsychotic

Caused neuroleptic malignant syndrome – fever, confusion, disorientation, muscle rigidity, profuse sweating and autonomic instability.

Atenolol

Beta blocker, treatment for high blood pressure.

Associated with 26% higher risk of stroke compared to newer drugs.

Avandia

Type 2 diabetes

Caused weight gain, bone fractures and heart disease.

Benoxaprofen

A non steroidal anti-inflammatory analgesic agent.

Potent phototoxic drug in elderly persons.

Benziodarone

A coronary vasodilator

Acute uric acid build up in the kidneys.

BIA 10- 2474

Pain relief and anxiety treatment

Volunteers in a Phase I clinical trial hospitalised with brain damage. One person died. January 2016.

Celebrex

Cox 2 inhibitor, arthritis painkiller

Risk of heart attack, weight gain, abdominal pain, headache, dyspepsia, diarhhoea, nausea, kidney failure, fainting, blurred vision, allergic reactions, chest pain, ringing in ears, intestinal bleeding etc

Cerivastatin

Treatment for high blood chloresterol,

Muscle toxicity

Cisapride

Gastrointestinal stimulant

Disorders of heart rhythm, headaches, diarhhoea, constipation, nausea and abdominal pain.

Clioquinol

Ingredient in anti-diarrhoea drugs

At least 10,000 people, and possibly up to 30,000, fell victim to SMON (subacute myelo-optic neuropatthy), a disease that causes numbness, weakness in the legs, paralysis, eye problems including blindness, all due to nerve damage.

Clozapine

Anti psychotic

Seizures, shaking hands, fainting, loss of bladder control, confusion, changes in vision, fever, severe muscle stiffness, sweating, changes in behaviour, sore throat, unusual bleeding or bruising, loss of appetite, upset stomach, yellowing of skin or eyes, flu like symptoms, lack of energy.

Dexfenfluramine

Weight loss

Cardiovascular side effects

Diethylstillbestrol (DES)

A synthetic estrogen prescribed to pregnant women to prevent miscarriage

Increased spontaneous abortions, premature births and neonatal deaths. Increased risk of vaginal cancer in daughters and granddaughters of users.

Domperidone

Treat symptoms of stomach disorders

Headaches, dizziness, dry mouth, nervousness, flushing, irritability, hot flushes, trouble sleeping, leg cramps, chest pain, slow/fast heart beat, discharge from breasts, swelling of feet and ankles, difficulty urinating, menstrual changes, sexual difficulties.

Droperidol

Antiemetic & anti psychotic

Spasms of the face, disorders of heart rhythm.

Enbrel

Treat rheumatoid arthritis, psoriasis, psoriatic arthritis, ankylosing spondylitis, juvenile rheumatoid arthritis.

Hypersensitivity reaction, sepsis, tuberculosis, reactivation of hepatitis B, malignancy, haematological reactions, autoimmunity, seizures and heart failure

Enzyme-inducing antiepileptic medicines

Epilepsy

Reduced bone mineral density and subsequent increased risk of fractures.

Eraldin

Treatment for heart conditions

Found to cause serious eye damage, including blindness. 23 deaths. Over a 1000 patients received compensation for the damage it caused.

Exanta

Blood thinner to treat thrombosis

Causes long term liver damage.

Ezetimibe

Reduces the amount of cholesterol and fatty substances in the blood.

Rapid onset of depression, hives, rashes, difficulty breathing or swallowing, hoarseness, swelling of the face, lips, ankles, throat, legs, hands eyes and tongue, upset stomach, tiredness, unusual bleeding and bruising, lack of energy, loss of appetite, chills, chest pain.

Fenfluramine

Anti obesity medication

Heart valve disease, pulmonary hypertension.

Grepafloxacin

Anti biotic

Caused disorders of heart rhythm

Humira

Rheumatoid arthritis treatment

Hypersensitivity reaction, sepsis, severe reactions occurred with patients who had tuberculosis or hep B or lupus, can cause swelling, shortness of breath, chills, flu symptoms, weight loss, fever, patchy skin, chest pain, coughing up blood, easy bruising, pale skin, unusual weakness.

Ibufenac

Non steroidal Anti inflammatory (Ibuprofen)

Caused severe liver damage.

Kava kava

Herbal remedy for stress and anxiety

Liver toxicity

Leflunomide

Anti inflammatory disease modifying anti rheumatic

Hepatotoxicity, nausea, diarrhea, hair loss, flu like symptoms, mild dizziness, chest pain, back pain, sore mouth, muscle cramping, numbness / tingling sensations.

Levacetylmethadol

Treatment for opium addiction

Withdrawn, caused severe cardiac disorders.

Methandrostenolone

Anabolic Steroid

Enlargement of male breasts, water retention, oily skin, acne, unwanted body hair, aggression, male pattern baldness, liver damage.

Metipranolol

Treatment of Glaucoma

Severe eye irritation or inflammation, slow heart beat or chest pain.

Mibefradil

Treatment of high blood pressure

Abdominal pain, belching, heartburn, stomach discomfort, flushing, headache, nausea, vomiting, pounding heart, stuffy nose, dizziness, lightheadedness, swelling legs, unusual tiredness.

Mumps vaccine

Prevention of mumps

Allergic reactions – difficulty in breathing or swallowing, hives, itching, reddening of skin, swelling of eyes, face or inside of nose, unusual tiredness or weakness. Other side effects include bruising or purple spots on skin, confusion, fever, headache, irritability, pain, tenderness, swelling of testicles, stiffneck and vomiting.

Naftidrofuryl oxalate injection

Treatment for disorder of blood flow to the brain

Cardio toxicity, rash, inflammation of liver, nausea, stomach pain.

Nomifensine

Anti depressant

Linked to kidney failure, anemia and death

Odanacatib

Treatment for osteoporosis 

Withdrawn from development in September 2016 due to high risk of atrial fibrillation and stroke. 

Olanzapine

Anti psychotic

Confusion, sluggishness, fever, disorientation, muscle rigidity, spasms, profuse sweating, autonomic instability, swelling of face, breathing problems, uncontrollable chewing and arm and leg movements, loss of memory, nervousness.

Opren

Arthritis drug.

Found to be highly toxic in humans, with 3,500 reports of harmful effects including 61 British deaths, mainly through liver damage in the elderly.

Osmosin

Non steroidal anti inflammatory

Stomach ulceration and death

Pacritinib

Treatment for rare blood cancer called myelofibrosis 

Trials halted in February 2016 as a number of volunteers taking part died from brain haemorrhages or heart failure. 

Paroxetine

Anti depressant and anxiety treatment

Suicidal ideation, serotonin syndrome, bipolar mania or hypomania, schizophrenia, jaw / neck and back muscle spasms, fever, chills, sore throat and flu like symptoms, jaundice, GI bleeding, fetal defects, withdrawal syndrome, headache, weight loss, nausea, dry mouth, sweating, drowsiness, insomnia, constipation or diarrhea, erectile dysfunction, tremor, vertigo, dizziness.

Pemoline

ADHD, and narcolepsy

Liver toxicity

phenylbutazone and oxyphenbutazone

Non steroidal anti inflammatory

Gastrointestinal ulcers, kidney damage, oral lesions, internal heamorrhage, decreased appetite, excessive thirst, suppression of white blood cell production, aplastic aenemia.

Prenylamine

Angina pectoris

Depletes myocardial catecholamine stores

Propanidid

Short acting general anaesthetic

Withdrawn due to causing anaphylactic reactions

Pulmonary surfactant

To increase pulmonary compliance

Increased mortality.

Risperdal

Antipsychotic medication used to treat schizophrenia and symptoms of bipolar disorder (manic depression). Also used in autistic children to treat symptoms of irritability.

Increased risk of strokes and death in elderly dementia patients, seizures, major weight gain, onset of diabetes and potentially fatal high blood sugar.

Ritalin and Dexamphetamine

Treatment of ADHD, especially in children.

Children as young as 5 suffered strokes, heart attacks, hallucinations and convulsions, shortness of breath, heart palpitations, hair loss, muscle spasms, severe abdominal pain, tremors, insomnia, severe weight loss, depression and paranoia.

Sertindole

Anti psychotic

Cardiac arrhythmias, also caused some deaths

Simvastatin

Control hypercholesterolemia & prevent cardio vascular disease

17 % patients died between December 2005 and February 2006. Common side effects include, diarrhea, abdominal pain, indigestion, weakness. Less common – joint pain, memory loss and muscle cramps

Suprofen

Non steroidal anti inflammatory.

Caused kidney toxicity, withdrawn from the market.

Temafloxacin

Anti biotics

Death, low blood sugar, hemolytic anemia, other blood cell abnormalities, kidney dysfunction resulting in renal dialysis, liver dysfunction, allergic reactions causing life threatening respiratory distress.

Terodiline

Treatment of urinary incontinence

Cardiac arrhythmias

Thalidomide

A sedative and to treat morning sickness in pregnant women.

Found to cause damage to the human foetus, resulting in 10,000 children born crippled and deformed with missing limbs.

TGN1412

Treatment of inflammatory conditions (especially rheumatism) and leukemia

Volunteers in a clinical trial suffered poor breathing, heavy swelling of neck and head, organ failure

Tolcapone

Treatment of parkinsons disease

Life threatening liver disease

Torcetrapib

Treatment of hypercholesterolemia

Up to 82 known deaths reported worldwide.

Trasylol

Used to prevent blood loss during surgery

Kidney problems, heart attacks and strokes

Triazolam

Sedative

Neuropsychiatric

Troglitazone

Diabetes

Causes liver damage, resulted in 28 deaths and 7 liver transplants.

Trovan

Anti biotic

Acute liver failures and deaths.

Vioxx

Painkiller for rheumatoid and osteoarthritis

Increased risk of cardiovascular events.

Voltaren

Non steroidal Anti inflammatory

Life threatening heart or circulation problems, including heart attack or stroke.

Zelmac

Treatment for irritable bowel syndrome

Studies have shown a link to heart attacks and strokes.

Zelmid

Anti depressant

Linked to Guillain Barre syndrome, liver damage

Zolpidem

Short term treatment of insomnia

Possible death or coma from overdose, anterograde amnesia, hallucinations, delusions, ataxia and poor motor coordination, increased appetite, decreased libido, altered thought patterns, extroversion.

Zomax

Arthritis treatment & anti inflammatory drug to treat post operative pain

Deaths and severe allergic reactions.

Table provided by our friends at Humane Research Australia 

 

You can also read other good examples in the Animal Aid, Scientific Case Against the use of Animals in Biomedical Research


Comments (0)


Add a Comment





Allowed tags: <b><i><br>Add a new comment:



RELATED ARTICLES

WHAT CAN YOU DO TO HELP?

JOIN US

Sign up to our newsletter and keep up with events and campaigns.

DONATE

Donate to us to help us have the resources to do what we do.