You can help!
Billy the beagle in this graphic was rescued from a closed vivisection laboratory by Huha. You can help by letting the government know that no animals, rats or dogs, should be put through what Billy went through.
For more info on Billy and his friends and family: http://www.huhacampaigns.org.nz/varc-beagles.html
What animals will be used?In 2012 the Ministry of Health (MoH) put forward a possible testing regime to Hon Peter Dunne that included an extensive amount of animal testing on multiple species that included the LD50 test. NZAVS obtained copies of the advice the proposed testing regime was based on and details of the testing regime. After we brought this to the attention of Green Party MP Mojo Mathers a front page story on the Sunday Star Times and Sunday News papers ran on 4 December 2012 that outlined the testing proposals. The tests proposed included acute and repeat dose toxicity trials on rodents and dogs. Peter Dunne confirmed this at the time and said in the media that testing on dogs was "an unpleasant but necessary reality". Report to the MoH advising animal testing MoH proposal for animal testing News media coverage from 4 Decemeber 2012
What tests will be done?Since the considerable public outrage on the idea of using animals to test recreational drugs the use of the LD50 test was ruled out. In line with advice submitted by NZAVS to the expert committee appointed by Dunne the proposed acute toxicity trials have also been ruled out. Details of what tests will be required are not finalised. It is looking like long-term repeat dose trials, genotoxicity trials and toxicokinetic investigations will be required. Initially the MoH was not going to require reproductive toxicity trials as they considered warning labels like are required for cigarettes and alcohol enough - it is considered inevitable that such drugs will be harmful to foetuses. Since then though we have been told that they may be required after all. The Psychoactive Substances Act requires any animal testing to meet the International Conference on Harmonisation guidelines for multidisciplinary testing of pharmaceuticals. Animal trials for repeat dose trials under these guidelines require tests on both small and large animals. The small animals used are typically rats or mice, the large animals are usually dogs but in a minority of cases monkeys are used. Two of the three genotoxicity trials proposed by the MoH do not use animals, a third does. These trials are done to try and find out if a drug causes genetic damage. If it does it is a reasonable indication it may be carcinogenic. Long term carcinogenicity trials have not been proposed at this stage as far as we know. Toxicokinetic trials investigate how a drug is metabolised by the body and passes through it. Crude animal trials developed decades ago basically just require animals to be exposed to drug by the same route humans will be for a period of time then they are killed and dissected so any organ damage can be looked at. The details of all these tests are outlined in the above advice to the MoH and the MoH report.
What are the non-animal tests available?For all of the types of tests the MoH is considering non-animal tests are available, many of which are already approved for regulatory use for pharmaceuticals. The NZAVS submissions on both the Psychoactive Substances Bill and the Animal Welfare Amendment Bill contain extensive information on the many non-animal tests available. The most recent of the two is below, most of the information is duplicated between the two as the National Party members of the Health Select Committee refused to consider our submission opposing animal testing. The image below from the July 2013 issue of our magazine compares some of the animal tests with their non-animal counterparts. For details on these and many more non-animal tests: NZAVS submission on the 2013 Animal Welfare Amendment Bill supporting a ban on animal testing of legal highs
But what about...?The two links above the graphic with the beagle under "Background information" may answer other questions. The first takes you too all our previous website news posts relating to legal highs testing. The second is the campaign website we produced in support of the petition we ran in conjunction with SAFE and the RNZSPCA and with support from HUHA. Do you have any other queries or questions? Please go to our contact page and ask us anything. We will answer all queries and update this page if it is a question others will likely be wondering about.
 National Animal Ethics Advisory Committee submission on the Animal Welfare Amendment Bill (see page four) National Animal Welfare Advisory Committee submission on the Animal Welfare Amendment Bill (see page five)