The only not-for-profit in NZ with its sole purpose to end animal experimentation
Getting Down to the Science!

Getting Down to the Science!

Find out why animal experimentation is scientifically flawed

Vivisection isn’t just barbaric because of the high level of suffering and pain that it inflicts on animals but also because it acts under the false guise of being for the greater good of human health. 

 

The Doctors Against Animal Experiments Germany had this clip created called "The Failure of Animal Experiments."

Each year millions of animals suffer and die in the labs around the world. All this is always justified by pointing out the benefits for people. But if you take a closer look at these animal experiments, then their benefits look doubtful, because these animals are not humans.... This short animated film explains why animal experiments are scientifically the wrong way of research.

 

 

To help explain the many scientific issues involved with animal-based research, we wanted to tell you our top five reasons for being anti-vivisection: 

Our Top Five Reasons for Being Anti-Vivisection!

 

1. Mice, rats and other animals are not accurate models for predicting the human response

Due to the large number of differences between species, including genetic, physiological, metabolic and psychological, animal-based research is far less reliable than flipping a coin! In reality, animal models can be used only as analogies for human systems.1
 
Different species often react differently to the same drugs or treatments. Penicillin is a great example. 
 
Penicillin can be:
- Fatal for guinea pigs and Syrian hamsters 2
- Effective in mice 3
- Metabolised too quickly in rabbits 4
- Teratogenic in rats (causes limb malformations in offspring)5
- Effective in humans 
 
With such a variety of reactions to penicillin in many different species, how do we know which animal model will be predictive for humans? This is one of the many issues in using animals to model human responses. Human-relevant research would provide a much more accurate result.
 
Here are a few examples of research conducted using animals that demonstrate that animals do not reliably predict the human response:
 
Animal Experimentation is Ineffective for Cancer Research: In 1971, the ‘War on Cancer’ was announced in the U.S.A. An overwhelming amount of animal-based cancer research has occurred since but has unfortunately not prevented cancer from continuing to be a significant threat to human health.6
 
Animal Experimentation is Ineffective for HIV and AIDS Research: HIV researchers have developed 90 vaccines that protect non-human animals from HIV infection; none of these vaccines are effective in humans. 7 Useful AIDS research has been advanced in the vast majority of cases due to the use of human models.8
 
Animal Experimentation is Ineffective for Stroke Research: Between 1993 and 2003, researchers developed fourteen neuroprotective treatments that were effective in non-human animals. All fourteen were ineffective in human patients.9
 
Animal Experimentation is Ineffective for Spinal Cord Injury Research: In a systematic review of animal-based research conducted to determine the viability of treatments for spinal cord injury, authors found that the highly variable results of the animal studies meant that human responses were impossible to predict. 10 
 
Animal Experimentation is Ineffective for Diabetes Research: Despite a considerable amount of literature published about type 2 diabetes (over 50 articles on rodent experimentation per month for the last 30 years) there are few treatments available for humans, and none of these prolongs life expectancy for patients 11. NOTE: In 2014, an estimated 422 million people had diabetes worldwide, which is 8.5% of the global population. 12 It is vital that relevant, human-based models are utilised for diabetes research.
 
Animal experimentation is ineffective for sepsis research: 150 cures developed for sepsis infections have been successful in mice. All of these failed and even caused the infection to worsen in some cases when used in humans.13

2. Animal-based research hurts humans too!

Results from animal-based research are misleading when they are applied to humans and can lead to adverse effects in human clinical trials.
 
Unfortunately, these unforeseen side effects can even be fatal to people. Adverse drug reactions that weren't predicted in animal trials have been recorded as the 4th-6th leading cause of death in US hospitals.14
 
 
Examples:
 
In March 2006, six human volunteers were injected with the experimental drug, TGN1412, which had previously been tested on mice, rats, rabbits and monkeys with no adverse effects.15For the human volunteers, the drug produced the opposite effect and several were left with permanent organ damage. 
 
In 2003, trials of an Alzheimer’s vaccine cured the disease in “Alzheimer’s mice.” The trial had to be stopped after the substance caused brain inflammation in humans.16
 
See many more cases where animal experimentation has gone wrong in the table below.
 

3. Misleading results from animal-based research may cause us to discard treatments that could help humans.

Examples:
 
Therapies that were nearly abandoned due to misleading results from animal-based research include Tamoxifen (one of our most effective drugs against certain types of breast cancer), which caused liver tumours in rats.17 
 
The now-highly-regarded leukaemia drug Gleevec caused severe liver toxicity in dogs.18 Fortunately, the manufacturers persisted with the development of this drug because it seemed so promising in human cell culture tests. 
 
Approximately 95% of experimental drugs fail in clinical studies because we cannot accurately predict how they will behave in humans based on laboratory and animal studies.19 We can only imagine how many of these could be useful human treatments if they weren’t tested on the wrong model first!
 

4. Time, money and other resources wasted on animal-based research could be directed into more relevant human-based tests.

The average cost to develop a new drug is USD 2.558 billion,20 and if proven effective, can take 12 years to reach human patients.21
 
Time and time again, misleading results from animal-based research have resulted in findings that aren’t useful for humans. No wonder it takes so long and costs so much to get a useful drug onto shelves!
 
Examples:
 
It took over thirty years of diabetes research using rodents before “we” discovered that the internal structure and function of the human pancreatic islet cell, which is central to the development of diabetes, is dramatically different from that in the “well-studied rodent”.22
 
One of the researchers, Per-Olof Berggren, adjunct professor at the Diabetes Research Institute and professor at the Rolf Luft Center for Diabetes Research at Karolinska Institutet in Stockholm, Sweden, stated that:
 
“We can no longer rely on studies on mice and rats. It is now imperative that we focus on human islets. At the end of the day, it is the only way to understand how they function.” 23
 
AIDS/HIV research has been carried out on non-human primates for decades, yet all of approximately 90 HIV vaccines that succeeded in animals failed in humans.24
 
Cancer research using rodents has proven over the past 30 + years, to be a massive waste of time. Even the head of America’s most prominent cancer institute has admitted so. “We have cured mice of cancer for decades – and it simply didn’t work in humans.” Dr Richard Klausner, former director of the US National Cancer Institute 25
 
To help humans, we need to shift towards more relevant and accurate human-based research. Read more about these better methods HERE

5. Animal experimentation is cruel

Although there are many scientific problems with animal-based research, it is also important to point out the ethical issues involved.
 
Because it’s legal, many people believe that the animals used in animal experiments won’t feel any pain or fear. This belief is not true.
 
Experiments are permitted by animal ethics committees that you wouldn’t wish upon your worst enemy.
From rats being force-fed ecstasy as an attempt to measure drug addiction in humans, to live pigs being shot in the head to try and replicate blood spatter patterns in humans, the pain and fear that animals are made to endure is unjust. 
 
Non-human animals are now recognised as sentient beings in New Zealand law.26 Sentient beings deserve a life free from fear and pain.
 
Join NZAVS and help us create a better world for both humans and animals!
Become an NZAVS Animal Advocate HERE
 
 
 

 

Other Dangerous Drugs

With 9/10 experimental drugs failing in humans that have worked in animals, it is no surprise that there are many examples where humans have had unexpected responses to drugs due to misleading animal experiments.  

Here is a list of cases where animal experiments have failed to predict the human response (This is not a complete list, it is just a few of the many examples):

 

Drug

Purpose

Result

Amrinone

To treat heart failure

Caused thrombocytopenia - a lack of blood cells needed for clotting in 20% of patients taking the drug on a long-term basis.

Ariprazole

An antipsychotic

Caused neuroleptic malignant syndrome – fever, confusion, disorientation, muscle rigidity, profuse sweating and autonomic instability.

Atenolol

Beta blocker, treatment for high blood pressure.

Associated with 26% higher risk of stroke compared to newer drugs.

Avandia

Type 2 diabetes

Caused weight gain, bone fractures and heart disease.

Benoxaprofen

A non-steroidal anti-inflammatory analgesic agent.

Potent phototoxic drug in elderly persons.

Benziodarone

A coronary vasodilator

Acute uric acid build up in the kidneys.

BIA 10- 2474

Pain relief and anxiety treatment

Volunteers in a Phase I clinical trial hospitalised with brain damage. One person died. January 2016.

Celebrex

Cox 2 inhibitor, arthritis painkiller

Risk of heart attack, weight gain, abdominal pain, headache, dyspepsia, diarrhoea, nausea, kidney failure, fainting, blurred vision, allergic reactions, chest pain, ringing in ears, intestinal bleeding etc

Cerivastatin

Treatment for high blood cholesterol

Muscle toxicity

Cisapride

Gastrointestinal stimulant

Disorders of heart rhythm, headaches, diarrhoea, constipation, nausea and abdominal pain.

Clioquinol

Ingredient in anti-diarrhoea drugs

At least 10,000 people, and possibly up to 30,000, fell victim to SMON (subacute myelo-optic neuropathy), a disease that causes numbness, weakness in the legs, paralysis, eye problems including blindness, all due to nerve damage.

Clozapine

Anti psychotic

Seizures, shaking hands, fainting, loss of bladder control, confusion, changes in vision, fever, severe muscle stiffness, sweating, changes in behaviour, sore throat, unusual bleeding or bruising, loss of appetite, upset stomach, yellowing of skin or eyes, flu-like symptoms, lack of energy.

Dexfenfluramine

Weight loss

Cardiovascular side effects

Diethylstilbestrol (DES)

A synthetic estrogen prescribed to pregnant women to prevent miscarriage

Increased spontaneous abortions, premature births and neonatal deaths. Increased risk of vaginal cancer in daughters and granddaughters of users.

Domperidone

Treat symptoms of stomach disorders

Headaches, dizziness, dry mouth, nervousness, flushing, irritability, hot flushes, trouble sleeping, leg cramps, chest pain, slow/fast heartbeat, discharge from breasts, swelling of feet and ankles, difficulty urinating, menstrual changes, sexual problems.

Droperidol

Antiemetic & antipsychotic

Spasms of the face, disorders of heart rhythm.

Enbrel

Treat rheumatoid arthritis, psoriasis, psoriatic arthritis, ankylosing spondylitis, juvenile rheumatoid arthritis.

Hypersensitivity reaction, sepsis, tuberculosis, reactivation of hepatitis B, malignancy, haematological reactions, autoimmunity, seizures and heart failure

Enzyme-inducing antiepileptic medicines

Epilepsy

Reduced bone mineral density and subsequent increased risk of fractures.

Eraldin

Treatment for heart conditions

Found to cause severe eye damage, including blindness. 23 deaths. Over a 1000 patients received compensation for the damage it caused.

Exanta

Blood thinner to treat thrombosis

Causes long-term liver damage.

Ezetimibe

Reduces the amount of cholesterol and fatty substances in the blood.

Rapid onset of depression, hives, rashes, difficulty breathing or swallowing, hoarseness, swelling of the face, lips, ankles, throat, legs, hands eyes and tongue, upset stomach, tiredness, unusual bleeding and bruising, lack of energy, loss of appetite, chills, chest pain.

Fenfluramine

Anti-obesity medication

Heart valve disease, pulmonary hypertension.

Grepafloxacin

Antibiotic

Caused disorders of heart rhythm

Humira

Rheumatoid arthritis treatment

Hypersensitivity reaction, sepsis, severe reactions occurred with patients who had tuberculosis or hep B or lupus, can cause swelling, shortness of breath, chills, flu symptoms, weight loss, fever, patchy skin, chest pain, coughing up blood, easy bruising, pale skin, unusual weakness.

Ibufenac

Non steroidal Anti inflammatory (Ibuprofen)

Caused severe liver damage.

Kava kava

Herbal remedy for stress and anxiety

Liver toxicity

Leflunomide

Anti-inflammatory disease modifying anti-rheumatic

Hepatotoxicity, nausea, diarrhoea, hair loss, flu-like symptoms, mild dizziness, chest pain, back pain, sore mouth, muscle cramping, numbness/tingling sensations.

 

 


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